Numerous studies have shown that chronic inflammation of May as a catalyst for Heart and Gefakrankheiten. For decades doctors have viewed heart disease in relation to the plaque-building and clogged arteries. Cholesterol and triglycerides were the villains. The theory was that years of poor diet fatty deposits or plaques would begin to deal with in the arteries. Finally, this plaque would grow so large that they cut off the blood supply to the heart resulting in angina (chest pain), high blood pressure, and for the untreated with cholesterol-lowering medications, a heart attack. The people began to be concerned about their total cholesterol and could even tell the difference between low-density lipids (LDL) or bad cholesterol and high-density lipids (HDL) or "good" cholesterol.
Doctors militant advocates cholesterol levels below 200 (This figure has steadily declined over the years). The LDL and HDL level was equally important. A high LDL and low HDL spelling difficulties. Cholesterol were attacked with lipid (blood fat) lowering drugs, including statins, Lipitor, Zocor, Crestor, Vytorin and others.
However, there is a problem with the script. Half of all heart attacks occur in people with normal cholesterol levels! And to their surprise diagnostic imaging showed that the most dangerous plaques were not large.
In fact that half of all those who have coronary heart disease, none of the traditional risk factors such as above.
Arterial Damage
There are dozens of theories which attempt to explain , The cause of atherosclerosis and arteriosclerosis. Scientific studies have documented the negative effects of total cholesterol, elevated low-density lipids (LDL), decreased high-density lipids (HDL), homocysteine, fibrinogen, oxidative stress, elevated C-reactive protein (CRP), inflammation, sedentary way of life , Diabetes, obesity, infections, and stress.
The most widely accepted theory is based on the idea that the damage to the arterial wall from the above list (inflammation, high blood pressure, elevated LDL, etc.) initiates physiological changes, then create Atherosclerosis.
The endothelial lining of the artery is damaged from physical, chemical, viral, bacterial, or immune reactions. Once damaged, the injured tissue is permeable to lipoproteins (fat, protein). The arterial linings connective tissue begins with the division, which pulls cholesterol deposits. Large white blood cells known as monocytes and clotting platelets adhere to the injured area causing plaque to form.
A fibrous cap (consisting of collagen, elastin and glycosaminoglycans) forms on the injured area. Cholesterol and fat begin to build up around the site and a arthroma is. The arthroma of fibrous plaque coated May continue to grow until they finally blocked the flow of blood through the artery. It takes usually a ninety percent blockade against the symptoms of atherosclerosis is experienced.
Arthromas May calcify, hardening in a process known as atherosclerosis. Atherosclerosis of the coronary arteries can lead to thrombosis (blood clot), which is as angina pectoris (chest pain) or a heart attack. Atherosclerosis of cerebral (brain) arteries can be a stroke.
Elevated Fibrinogen
Fibrinogen is a protein involved in the regulation of blood clotting and platelet clumping.
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fibrinogen increased by an inflammation, oxidative damage, smoking, stress, oral contraceptives and aging.
Elevated fibrinogen levels has shown that the incidence of stroke.
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The New England of Medicine reported that people with elevated fibrinogen were twice as likely to die of a heart attack.
Research shows that it is best to keep fibrinogen levels below 300mg/dl.
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garlic acts as a natural blood thinner. This helps to prevent clotting in connection with overcapacity levels.
Recommended fibrinogen 4000 mcg dose is a day.
Fish oil supplement helps reduce fibrinogen levels.79 recommended dose is 4-9 grams of an day.
Curcumin is the yellow pigment in Turmeric. It is a powerful antioxidant with potent anti-inflammatory properties. Curcumin's ability to reduce inflammation can squelch on fibrinogen levels.
Ginkgo Biloba has over 300 clinical trials of its use in the management of cardiovascular and cognitive disorders. Ginkgo as a vasodilator to lower blood pressure, improve blood flow to the extremities (legs), and reduces fibrinogen levels.
One study showed that of 40 mg of ginkgo, the twice per day reduced the symptoms associated with intermittent claudication (unnecessary traffic on the legs ) Up to 45 percent.
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recommended dose is 120mg tablet film day.
C-Reactive Protein
C-reactive protein (CRP) is a marker associated with inflammation. A study in the New England Journal of Medicine found that CRP is a strong predictor of heart attack and stroke. Men with the highest percentage points had three times the risk of heart attack and twice the risk for stroke.82
Elevated CRP may indicate inflammation and subsequent damage arterial wall, then triggers a chain reaction leading to atherosclerosis.
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stroke patients with the highest CRP levels were 2 /4 times more likely to die within the next 12 months compared to those with the lowest CRP.
Vitamin C lowers C-reactive protein, blood pressure, fibrinogen levels, and Lp (a ) Levels.
A 10-year study showed that the 11,000 plus individuals with a high level of vitamin C prolongs life and reduces mortality from cardiovascular disease by 45 percent.
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recommended dose is 2-6 grams a day.
Homocysteine
Homocysteine is a byproduct of the conversion of the amino acid cysteine in methionine. If homocysteine is not in methionine, it will begin in the endothelial cells of the arterial wall. This leads to plaque formation and possible arterial obstruction. Homocysteine accelerates the oxidation (toxic damage) of cholesterol, which is then tied to small LDL particles. Macrophages then the particles and convert them into plaque.
The European Journal of Medicine reported that 40 percent of those who had strokes also had elevated homocysteine levels compared to only 6 percent of controls.
Higher levels of homocysteine increases the incidence of deep vein thrombosis THROMBOSIS.
A Norwegian study involving over 4700 men and women showed that for every 5-millimol /L increase in plasma homocysteine caused the number of deaths from all sources to jump to 49 percent. They included a 50 percent increase in cardiovascular deaths and a 26-percent increase in cancer therapy deaths.
Homocysteine levels are treated under 7micromol /L of blood plasma. Laboratories generally advocate that homocysteine levels are normal up to 15, However, the risk of heart attack increases significantly if homocysteine levels go up 6 /3 points.
Based hospital on random blood tests, the prevalence of elevated homocysteine levels in elderly patients with chronic illnesses is estimated to be 60-70 percent. Seventy percent of people with cardiovascular disease had elevated homocysteine levels. And 63 percent of people with cognitive dysfunction had elevated homocysteine levels levels.
Individuals with elevated homocysteine levels should supplement with 500-800mcg folic acid, 1000-3000mcg of B12, 100-259mg of B6, and if necessary 500-900mg of trimethylglycine (TMG), also known as betaine.
About Dr. Murphree
Dr. Murphree is a board certified nutritional specialist and chiropractic physician who has been in private practice since 1990. He is the founder and past clinic director for a large integrated medical practice located on the campus of Brookwood Hospital in Birmingham Alabama. The clinic was staffed with medical doctors, chiropractors, acupuncturists, nutritionists, and massage therapists. The clinic combined prescription and natural medicines for acute and chronic illnesses. He is the author of 5 books for patients and doctors, including "Treating and Beating Fibromyalgia and Chronic Fatigue Syndrome," ""Heart Disease What Your Doctor Won't Tell You'" and "Treating and Beating Anxiety and Depression with Orthomolecular Medicine."
His website is at http://www.treatingandbeating.com
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